Gregory House (Hugh Laurie), House

He’s rude, crude and socially unacceptable — but is House also sexy? Is it the stubble? The piercing blue eyes? His razor-sharp wit and intelligence? Perhaps the combination is the winning prescription

Robert Chase (Jesse Spencer), House

The eyes! The hair! The accent! Chase is a triple threat for the lovely ladies of Princeton-Plainsboro Teaching Hospital. So why did it take him three seasons to finally hook up with Cameron? Though Chase tends to side with Surly McSurly House, he revealed a softer, more spiritual side after telling a patient he was a seminary student before heading into medicine. Bring on the Thorn Birds moments!

Rest: The 12 Hottest TV Doctors